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Somatic mutational profiling identifies aggressive and indolent disease phenotypes in well-differentiated pancreatic neuroendocrine tumors

Abstract: Integration of biomarkers into clinical management of well-differentiated pancreatic neuroendocrine tumors (PNETs) remains limited due to disease rarity and…

Date: 2026-05-08

Systematic monitoring identified a high incidence of hypopituitarism following combined ipilimumab plus nivolumab therapy for metastatic melanoma

Abstract: Combination immunotherapy with ipilimumab and nivolumab has improved long-term progression-free and overall survival in patients with metastatic melanoma. Unfortunately,…

Date: 2026-05-08

A case report of acute carcinoid heart failure during lutetium-177 dotatate–triapine treatment for well-differentiated neuroendocrine tumors

Abstract: Well-differentiated neuroendocrine tumors (NETs) have a high indolent local progression rate when resistance develops to biologic or cytotoxic chemotherapy.…

Date: 2026-05-08

A blood-based immune-suppressive index stratifies immunotherapy outcomes in advanced NSCLC

Abstract: Immune checkpoint inhibitors (ICIs) provide durable benefit for a subset of patients with advanced non-small cell lung cancer (NSCLC), however predictive biomarkers…

Date: 2026-05-08

Impact of socioeconomic status on tumor stage, molecular subtype distribution, treatment adherence, and survival outcomes in breast cancer

Abstract: Socioeconomic status (SES) is a key determinant of cancer outcomes, influencing access to screening, early diagnosis, treatment adherence, and survival. Socioeconomic…

Date: 2026-05-08

Mortality trends of cardiac, mediastinal and pleural malignancies in the United States, 1999–2020: a population-based analysis of demographic and geographic disparities

Abstract: Cardiac, mediastinal, and pleural malignancies represent rare but clinically significant thoracic neoplasms. Despite their clinical importance, comprehensive…

Date: 2026-05-08

PFO closure in ischemic stroke: insights from a single-center real-world cohort

Abstract: Indications for patent foramen ovale (PFO) closure after ischemic stroke are primarily guided by the Risk of Paradoxical Embolism (RoPE) score and the PFO-associated…

Date: 2026-05-08

Impact of COVID-19 history on the prevalence of coronary slow flow: a comparative study in unstable angina patients

Abstract: This study investigated coronary slow flow (CSF) prevalence in post-COVID-19 patients presenting with unstable angina (UA) and angiographically normal coronary arteries.…

Date: 2026-05-08

Efficacy and safety of finerenone in chronic kidney disease stages 3–4 in diabetic and non-diabetic patients with an eGFR 20–60 mL/min: a prospective cohort study

Abstract: Finerenone, when added to the standard-of-care treatment for chronic kidney disease (CKD), can effectively slow its progression. While previous trials have primarily…

Date: 2026-05-08

Real-world experience with sodium-glucose cotransporter 2 inhibitors in adults with Fontan circulatory failure

Abstract: Patients with Fontan physiology frequently develop Fontan circulatory failure (FCF), but there are no evidence-based pharmacological treatment options. This study…

Date: 2026-05-08