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Serum and cerebrospinal fluid neuroinflammatory biomarkers and trimethylamine N-oxide: associations with white matter lesion severity

Abstract: This study aimed to investigate the association between a multi-panel biomarker profile across the blood-brain barrier and the severity of white matter lesions (WML) in…

Date: 2026-05-08

Psychometric evaluation of the Chinese version of the abbreviated technology anxiety scale among older patients with stroke: a translation and validation study

Abstract: In the clinical care and rehabilitation of older patients with stroke, the application of technology has become increasingly prevalent, yet the issue of technology…

Date: 2026-05-08

Symptomatic stratification based on morphological features of carotid web (SCORE-WEB)

Abstract: Carotid web (CaW) is an underrecognized variant of fibromuscular disease increasingly implicated in cryptogenic ischemic stroke. Several morphologic features, including…

Date: 2026-05-08

Distinct remission immune architectures under rituximab and azathioprine in AQP4-IgG-positive neuromyelitis optica spectrum disorder

Abstract: Maintenance immunotherapy is effective in AQP4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD), but how mechanistically distinct maintenance therapies…

Date: 2026-05-08

Association of NLRP3 rs10754558 polymorphism with inflammasome-related cytokine responses in chronic spontaneous urticaria

Abstract: Chronic spontaneous urticaria (CSU) is a clinically heterogeneous inflammatory condition affecting the skin, in which mechanisms beyond histamine-mediated mast cell…

Date: 2026-05-08

Evaluation of risk factors and treatment options associated with extra-urogenital Mycoplasma hominis infections

Abstract: This study aimed to analyze clinical risk factors and treatment outcomes of different antibiotic regimens for extra-urogenital Mycoplasma hominis ( M. hominis )…

Date: 2026-05-08

Calculated globulin as a surrogate marker for hypogammaglobulinemia: establishing clinical decision limits in a Brazilian population cohort

Abstract: Inborn errors of immunity (formerly primary immunodeficiencies) encompass a group of genetic disorders characterized by defects in innate and/or adaptive immunity. Serum…

Date: 2026-05-08

Double-dose furmonertinib for patients with osimertinib-resistant advanced NSCLC: therapeutic efficacy and safety

Abstract: Epidermal growth factor receptor (EGFR) gene mutations play a key driving role in the development and progression of lung cancer. Currently, EGFR tyrosine kinase…

Date: 2026-05-08

The prognostic value of peripheral blood inflammatory markers in patients with HER2-positive metastatic breast cancer treated with pyrotinib

Abstract: Different peripheral blood markers have been reported to be involved in different stages of breast cancer development and metastasis. However, the association between…

Date: 2026-05-08

Translational 3D in vitro models for immunotherapy testing: from reconstituted organoid co-culture assays to autologous ex vivo patient tissues

Abstract: The lack of patient-relevant, clinically predictive models for early (immuno)-oncology (IO) drug discovery is a significant challenge for drug developers. Advances in…

Date: 2026-05-08