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Compositional maturation of the microbiome and adaptive immunity in the postnatal period

Abstract: Recent research has highlighted the role of the gut microbiome in shaping the development and function of the mammalian immune system. Interactions between these complex…

Date: 2026-05-05

Real-world use of brexpiprazole during inpatient treatment for schizophrenia: continuation, discontinuation, and concomitant psychotropics

Abstract: In the treatment of schizophrenia, antipsychotics used during acute inpatient care must control acute symptoms while remaining sufficiently tolerable to support…

Date: 2026-05-05

Psychosocial burden of discrimination based on sexual orientation in university students—A cross-sectional analysis

Abstract: Sexual minority individuals continue to face prejudice and discrimination within medical care and academic settings. This contributes to elevated stress levels, which…

Date: 2026-05-05

Benchmarking publicly accessible large language models for high-myopia multiple-choice question generation in digital ophthalmic education and public health training

Abstract: Digital tools are reshaping public health education and training, yet evidence on whether large language models (LLMs) can generate specialist ophthalmic teaching…

Date: 2026-05-05

Mechanism of periocular acupuncture in alleviating dry eye neuropathic pain via regulation of the “periocular acupoint–trigeminal ganglion–ventral posteromedial thalamic nucleus” pathway

Abstract: Dry eye disease (DED) is a common ocular surface disorder characterized by tear film instability and trigeminal nerve-mediated corneal hyperesthesia. Periocular…

Date: 2026-05-05

Leukemia disease burden and quality of care among adolescents and young adults in China compared to global patterns: a comprehensive analysis from 1990 to 2021

Abstract: Leukemia is a major global public health challenge, particularly among adolescents and young adults (AYAs) aged 15–39?years, who face distinct biological and social…

Date: 2026-05-05

The relationship between nurse managers' empowering behaviors and nurses' work engagement: a latent profile analysis

Abstract: To explore the latent profiles of nurse managers' empowering behaviors in Chinese tertiary general hospitals and to analyze differences in nurse work engagement across…

Date: 2026-05-05

Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis

Abstract: Numerous studies indicated inflammatory bowel disease (IBD) patients suffered from sleep disturbances. Although melatonin (MT) exerts positive effects on maintaining…

Date: 2026-05-05

The clinical value of endoscopic ultrasonography combined with endoscopic treatment for upper gastrointestinal lifting lesions

Abstract: The present investigation is designed to assess the synergistic impact of endoscopic ultrasonography (EUS)paired with endoscopic therapy in addressing upper…

Date: 2026-05-05

A comparative analysis of health-related and individual quality of life in people with Parkinson’s disease

Abstract: Quality of life (Qol) results from a complex interplay of physical, mental, and social aspects. Traditional assessments of Qol may not adequately describe well-being in…

Date: 2026-05-05