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The novel GLP-1/GIP dual receptor agonist DA5-CH is superior to tirzepatide and exendin-4 in the 6-OHDA Parkinson rat model

Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder for which there is no cure. Diabetes is one of the risk factors for developing PD. Tirzepatide is a…

Date: 2026-05-05

A multimodal machine learning model for predicting postoperative worsening of FOGQ in Parkinson’s disease following STN-DBS

Abstract: To develop and validate a multimodal machine learning model to predict postoperative worsening of freezing of gait questionnaire (FOGQ) scores in patients with…

Date: 2026-05-05

Antigen-specific tolerance and control of autoimmunity effected by liver sinusoidal endothelial cells is unimpaired in liver fibrosis

Abstract: Liver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune…

Date: 2026-05-05

Parenteral neonatal priming followed by heterologous mucosal booster favors IgM + memory B cell induction over systemic plasma cell differentiation

Abstract: Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study…

Date: 2026-05-05

T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype

Abstract: STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector…

Date: 2026-05-05

Multiple malignant primary tumors in dogs: an Italian registry-based epidemiological study

Abstract: In human oncology, patients diagnosed with a primary malignant tumor are known to have an increased risk of developing subsequent malignancies. In veterinary medicine,…

Date: 2026-05-05

STC1 promotes colorectal cancer invasion and migration by regulating M2 macrophage polarization via TGF-?1/Smad signaling pathway

Abstract: Colorectal cancer (CRC) mortality is largely attributable to invasion, migration, and an immunosuppressive tumor microenvironment. We examined the clinical relevance and…

Date: 2026-05-05

The higher dietary energy-to-fiber ratio is associated with an increased risk of poor blood pressure control among patients with essential hypertension: a cross-sectional study

Abstract: Dietary fiber (DF) and energy intake are two noted factors in the dietary management of hypertensive patients, which are associated with blood pressure (BP) control. We…

Date: 2026-05-05

Real-world evidence of lower-dose intensity of immune checkpoint inhibitors in MSI-H/dMMR gastrointestinal cancers from a resource-constrained setting

Abstract: Immune checkpoint inhibitors (ICIs) have markedly improved outcomes in metastatic microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR)…

Date: 2026-05-04

Assessment of bone density and microarchitecture in patients with familial partial lipodystrophy

Abstract: Familial partial lipodystrophy (FPL) is a rare condition related to partial deficiency of adipose tissue and consequent insulin resistance resulting in metabolic…

Date: 2026-05-04