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Clinical application of HMGB1-TLR4 signaling pathway-mediated neuroinflammatory markers in infantile epileptic spasms syndrome

Abstract: Infantile epileptic spasms syndrome (IESS) is a severe age-specific epileptic encephalopathy with unclear pathogenesis, and neuroinflammation is involved in its…

Date: 2026-05-01

Neurological manifestations in people with HIV in HAART era: a cross-sectional multicenter study

Abstract: The landscape of neurological manifestations of HIV remains unknown after HAART is applied. This study aimed to characterize the spectrum of neurological disorders in…

Date: 2026-05-01

A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model

Abstract: Chlamydia trachomatis ( Ct ) is the most common bacterial cause of sexually transmitted infection worldwide. Given the limited effectiveness of current Ct screening and…

Date: 2026-05-01

Cladribine treatment in pediatric-onset multiple sclerosis: real-world clinical outcomes and safety insights

Abstract: Pediatric-onset multiple sclerosis (POMS) poses unique therapeutic challenges due to high inflammatory activity, early cognitive and psychosocial impact, and…

Date: 2026-05-01

Effects of trimodal prehabilitation on quality of life and negative emotions in patients with advanced triple-negative breast cancer

Abstract: To assess the effectiveness of a four-week trimodal prehabilitation program in enhancing the quality of life, clinical symptoms, and negative emotions of stage IV…

Date: 2026-05-01

Development of an online prediction tool for immunotherapy-related adverse events in patients with advanced NSCLC based on machine learning and temporal validation

Abstract: Despite the widespread use of immune checkpoint inhibitors (ICIs) improving survival outcomes in non-small cell lung cancer (NSCLC) patients, immune-related adverse…

Date: 2026-05-01

Comparative molecular analysis of colorectal cancer in Saudi Arabia: distinct genetic alterations and clinical features

Abstract: Globally, colorectal cancer (CRC) stands as the third most common type of cancer, a ranking that has remained consistent over recent years. However, the scenario…

Date: 2026-05-01

Adherence to endocrine therapy and survival outcomes in hormone receptor–positive breast cancer

Abstract: To evaluate the association between adherence to adjuvant endocrine therapy and overall survival as well as breast cancer–specific survival in patients with hormone…

Date: 2026-05-01

The effects of SGLT2 inhibitors on atrial fibrillation recurrence and cardiac function after catheter ablation in patients with atrial fibrillation and heart failure: a retrospective cohort study and meta-analysis

Abstract: The impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) on postoperative atrial fibrillation (AF) recurrence and cardiac function in patients with AF and heart…

Date: 2026-05-01

Dickkopf 2 serves as a novel therapeutic target and prognostic biomarker in acute myeloid leukemia targeted by evodiamine

Abstract: Acute myeloid leukemia (AML) has seen a significant increase in cases recently, often leading to a poor outlook. Dysregulated cell death is a characteristic of AML that…

Date: 2026-04-30