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Intravitreal AAV vector delivery induces integrin-dependent ocular inflammation, complement activation, and antiviral and DNA damage responses

Abstract: Intravitreal delivery of adeno-associated virus (AAV) vectors offers a promising, minimally invasive strategy for retinal gene therapy, but remains limited by…

Date: 2026-04-22

Clinical, immunological, treatment characteristics, and outcomes in 22 patients with major histocompatibility complex class II deficiency

Abstract: Major histocompatibility complex (MHC) class II deficiency is a rare, life-threatening primary immunodeficiency that presents in early infancy with a SCID phenotype.…

Date: 2026-04-22

Serum steroid hormone profiles in reproductive-age women with systemic lupus erythematosus: associations with clinical manifestations and disease activity

Abstract: To characterize the serum steroid hormone profile in reproductive-age women with systemic lupus erythematosus (SLE) and evaluate its associations with clinical…

Date: 2026-04-22

Management of hypogammaglobulinemia in pediatric patients with refractory lupus nephritis: a focus on belimumab

Abstract: Although the use of belimumab in children with lupus nephritis (LN) has increased over the past few years, there are limited data on the safety of belimumab in such…

Date: 2026-04-22

Romiplostim N01 accelerates platelet engraftment in autologousstem cell transplantation using non-cryopreserved peripheral blood stem cells for plasma cell neoplasms

Abstract: Delayed platelet engraftment remains a major limitation of autologous stem cell transplantation (ASCT) for plasma-cell neoplasms. Romiplostim N01, a thrombopoietin…

Date: 2026-04-21

Haemonchus contortus infection alters parasitological, hematological, and colostrum profiles with metabolomic and lipidomic signatures in Florida cracker ewes during the peripartum period

Abstract: This study evaluated for the first time the effects of H. contortus infection on hematological and parasitological parameters, as well as on the composition,…

Date: 2026-04-21

A real-world data study on long-course venetoclax combined with hypomethylating agents in unfit patients

Abstract: This study aimed to investigate the efficacy, safety and prognostic value of measurable residual disease (MRD) in unfit AML patients treated with long-course venetoclax…

Date: 2026-04-21

Association of pericoronary fat attenuation index and insulin resistance for the risk of cardiometabolic multimorbidity: a cross-sectional study

Abstract: Cardiometabolic multimorbidity (CMM) has become an increasingly serious public health problem. Patients with type 2 diabetes mellitus (T2DM) often present with multiple…

Date: 2026-04-21

Vitamin D dynamics predict treatment response to intravenous glucocorticoids in thyroid-associated ophthalmopathy: a retrospective cohort study

Abstract: Intravenous glucocorticoids (IVGC) represent first-line therapy for active moderate-to-severe thyroid-associated ophthalmopathy (TAO). The relationship between vitamin D…

Date: 2026-04-21

Endothelial and cardiac dysfunction in long COVID With cardiovascular symptoms is associated with imbalance in the ADMA–DDAH–NOx pathway

Abstract: Post-acute sequelae of COVID-19 (PASC) commonly feature lingering symptoms of persistent cardiovascular pathology, yet the mechanisms remain incompletely defined. The…

Date: 2026-04-21