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Characterization of lactylation-related subtypes and diagnostic markers in myocardial ischemic reperfusion injury using weighted gene coexpression network analysis and machine learning

Abstract: Myocardial ischemia-reperfusion injury (MIRI) is a secondary injury that occurs after treatment for ischemic heart disease. This study aimed to identify key…

Date: 2026-04-21

A digital cognitive behavioral therapy program culturally adapted for Spanish-speaking individuals with alcohol use disorder: a stage 1 randomized clinical trial

Abstract: Digital formats are an important tool for making evidence-based therapies for alcohol use, such as cognitive behavioral therapy (CBT), more broadly available, yet only a…

Date: 2026-04-21

Comparison of anterior segment parameter measurements between Sirius Plus and Pentacam AXL

Abstract: This cross-sectional study compared the differences, consistencies, and correlations of the measurements of anterior segment biological parameters between Sirius Plus…

Date: 2026-04-21

The predictive accuracy of axial length to corneal curvature radius ratio for myopia in children and adolescents

Abstract: To analyze the association of axial length to corneal curvature radius ratio (AL/CR) and other ocular biometric parameters with myopia in children and adolescents. A…

Date: 2026-04-21

Duhuo Jisheng Decoction ameliorates experimental intervertebral disc degeneration by modulating immune-inflammatory responses through regulation of macrophage polarization

Abstract: The predominant cause of lower back pain (LBP) is intervertebral disc degeneration (IVDD), which has a substantial financial cost to both individuals and society. In the…

Date: 2026-04-21

Predicting long-term clinical mortality of elderly patients with vertebral compression fractures

Abstract: Vertebral compression fractures (VCFs) are prevalent among the elderly, often leading to significant complications and mortality. We aimed to develop and validate a…

Date: 2026-04-21

The predictive value of serum 25(OH)D, AQP4, and IL-4 levels for edema volume and clinical prognosis after traumatic brain injury

Abstract: This study aims to explore the associations between serum 25-hydroxyvitamin D (25(OH)D), aquaporin 4 (AQP4), and interleukin-4 (IL-4) levels with brain edema volume and…

Date: 2026-04-21

Robot-assisted radiofrequency ablation versus open resection for osteoid osteoma: an analysis of perioperative outcomes and a rare case of malignant transformation

Abstract: Osteoid osteoma (OO) is a rare benign bone tumor predominantly affecting young individuals, with malignant transformation reported only in exceptional cases. This study…

Date: 2026-04-21

Integrated single-cell and bulk transcriptomics identify autophagy-related immune-suppressive subtypes and a prognostic signature in colorectal cancer

Abstract: Colorectal cancer still causes many cancer deaths, and patient outcomes differ a lot. The tumor microenvironment can shape tumor growth and treatment response. Autophagy…

Date: 2026-04-21

Elevated serum sortilin reflects inflammatory burden and coagulation dysfunction in ulcerative colitis

Abstract: Sortilin, a multifunctional receptor, is implicated in inflammatory signaling; however, its clinical significance in ulcerative colitis (UC) remains unclear. This study…

Date: 2026-04-21