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Robot-assisted radiofrequency ablation versus open resection for osteoid osteoma: an analysis of perioperative outcomes and a rare case of malignant transformation

Abstract: Osteoid osteoma (OO) is a rare benign bone tumor predominantly affecting young individuals, with malignant transformation reported only in exceptional cases. This study…

Date: 2026-04-21

Integrated single-cell and bulk transcriptomics identify autophagy-related immune-suppressive subtypes and a prognostic signature in colorectal cancer

Abstract: Colorectal cancer still causes many cancer deaths, and patient outcomes differ a lot. The tumor microenvironment can shape tumor growth and treatment response. Autophagy…

Date: 2026-04-21

Elevated serum sortilin reflects inflammatory burden and coagulation dysfunction in ulcerative colitis

Abstract: Sortilin, a multifunctional receptor, is implicated in inflammatory signaling; however, its clinical significance in ulcerative colitis (UC) remains unclear. This study…

Date: 2026-04-21

Bidirectional Mendelian randomization analysis of hypertension, coronary artery disease, and gastric cancer with supplementary clinical data

Abstract: The relationship between gastric cancer and cardiovascular traits, including hypertension and coronary artery disease (CAD), remains incompletely understood.…

Date: 2026-04-21

An analysis of factors and pathways related to rehabilitation motivation in stroke patients based on self-determination theory

Abstract: Based on self-determination theory, this study investigates the current state of rehabilitation motivation among stroke patients and its psychosocial correlates,…

Date: 2026-04-21

Mean systolic blood pressure upon admission and clinical outcomes after endovascular treatment in patients with large vessel occlusion beyond 24 hours

Abstract: Recently, several clinical studies have shown that higher systolic blood pressure (SBP) upon admission is associated with poor clinical outcomes in patients with…

Date: 2026-04-21

Clinical and biological factors associated with the presence of peripheral neuropathy in patients with rheumatoid arthritis

Abstract: Immune dysfunction in rheumatoid arthritis (RA) is a contributing factor to the development of peripheral neuropathy (PN). The objective of our study was to investigate…

Date: 2026-04-21

High-risk and low-risk human papillomavirus detection in self-collected samples compared to clinician-collected samples in a Polish population

Abstract: Persistent infections with human papillomavirus (HPV) cause approximately 95% of cervical cancers. The introduction of cytology screening has, however, significantly…

Date: 2026-04-21

Mast cell release of TNF-? indirectly contributes to recalling B cells in the colorectal cancer milieu through the CCL20/CCR6 axis

Abstract: In colorectal cancer (CRC), mast cells (MCs) modulate tumor and immune cell interactions, influencing patient prognosis, though their role remains not fully elucidated.…

Date: 2026-04-21

Assessment of real-world surveillance strategies for patients undergoing systemic therapy for brain metastases

Abstract: Radiotherapy has long been first-line treatment for brain metastases. However, CNS penetrating systemic therapies are increasingly used as first-line alternatives. There…

Date: 2026-04-20