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LINC02470 impairs natural killer cell cytotoxicity by epigenetically targeting the natural cytotoxicity triggering receptor 1

Abstract: Natural killer cells (NK cells) play a critical role in the surveillance of tumor immunity. However, NK cell-based immunotherapy, including autologous and allogeneic NK…

Date: 2026-04-16

The profile of clinical and laboratory features of Chinese VEXAS syndrome patients with hematological abnormalities: a single-center case series

Abstract: VEXAS syndrome is a recently characterized hemato-inflammatory disorder caused by somatic mutations in the X-linked UBA1 gene in hematopoietic cells, which remains…

Date: 2026-04-16

Macrophage and IL-6 signaling modulate multiple myeloma progression and response to metformin and CAR-T cell therapy

Abstract: The tumor microenvironment (TME) plays a crucial role in tumor progression and therapeutic response. Monocytes and macrophages, depending on their phenotype, can either…

Date: 2026-04-16

Single-cell landscape of melanoma reveals ETV5-driven C3 ID4 + tumor subpopulation with extracellular vesicle-associated immunosuppressive and pro-metastatic potential

Abstract: Malignant melanoma is characterized by marked intratumoral heterogeneity and an immunosuppressive tumor microenvironment (TME), and resistance to immunotherapy remains…

Date: 2026-04-16

Economic cost of Hansen’s disease: an overview of social security expenditures

Abstract: Brazil is the second highest worldwide regarding new cases of Hansen’s disease (HD), with over 20,000 diagnoses annually. Late detection often results in severe…

Date: 2026-04-16

Clinical application of ozone hydrotherapy combined with scalp complex acid treatment for moderate to severe scalp seborrheic dermatitis

Abstract: This study evaluates the effectiveness of combining ozone hydrotherapy with scalp complex acid in treating scalp seborrheic dermatitis (SSD). A total of 96 patients with…

Date: 2026-04-16

Real-world skin and dermatology-specific quality-of-life outcomes and a nomogram to predict skin response to secukinumab in Chinese psoriatic arthritis patients: a multicenter retrospective cohort study

Abstract: Real-world data on secukinumab in Chinese psoriatic arthritis (PsA) patients remain limited, particularly regarding short-term cutaneous response, dermatology-specific…

Date: 2026-04-16

Prevalence of polycystic ovary syndrome among adolescents depending on the adopted diagnostic criteria

Abstract: PCOS is a common endocrine disorder that impacts hormonal, metabolic, and reproductive health. Its prevalence is steadily increasing, including in the pediatric…

Date: 2026-04-16

Adherence to dietary and physical activity guidelines and influencing factors among pregnant women: a cross-sectional study in China

Abstract: The diet and physical activity of pregnant women are crucial for maternal and fetal health. Many countries have developed guidelines. Research shows higher adherence to…

Date: 2026-04-16

Deep learning accurately and reliably segments pelvic vascular structure in CT scans of gynecologic cancer patients

Abstract: Accurate identification of pelvic vascular structures is critical for safe and effective gynecologic cancer surgery, yet intraoperative recognition of the internal iliac…

Date: 2026-04-16