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A truncating ELF4 variant in a pediatric patient with autoinflammatory disease and cell type-specific immune alterations

Abstract: ELF4 is an ETS family transcription factor involved in immune regulation, including antiviral responses and inflammatory signaling. Germline loss-of-function variants in…

Date: 2026-09-07

Research on the utilization of community health services and its determinants among older adults: a cross-sectional study in Liuzhou City

Abstract: This single-center, cross-sectional study investigates the health management demands, service utilization patterns, and their determinants among the older adults in a…

Date: 2026-09-07

Perceived epilepsy-related support and enabling environments and associated caregiver factors in rural South Africa: a cross-sectional study in Limpopo and Mpumalanga

Abstract: Family caregivers are important sources of support for people with epilepsy (PWE), particularly in rural settings where formal services may be limited. However, less is…

Date: 2026-09-07

Past-month alcohol use in relation to the COVID-19 lockdown in 13 Indian states and union territories: gender, socioeconomic status, and state alcohol policy differences

Abstract: This study examined whether past-month alcohol use after the lockdown was higher or lower than expected based on the pattern observed before the lockdown in 13 Indian…

Date: 2026-09-07

Thyroid autoimmunity is associated with increased uterine artery blood flow resistance and predicts adverse pregnancy outcomes in women with unexplained recurrent pregnancy loss: a retrospective cohort study

Abstract: Uterine artery blood flow resistance is critical for endometrial receptivity and successful implantation. Thyroid autoimmunity (TAI) is prevalent in recurrent pregnancy…

Date: 2026-09-07

Differentiating the potential of continuum beliefs to reduce the public stigma of schizophrenia, depression, and alcohol dependence: associations with illness recognition and treatment recommendations

Abstract: Promoting continuum beliefs has been discussed as a strategy for stigma reduction. The current study examines associations of continuum beliefs with stigma aspects…

Date: 2026-09-07

Disruption of amino acid metabolism in acute cerebrovascular diseases: diagnostic and pathobiochemical perspectives

Abstract: Early differential diagnosis of acute cerebrovascular events remains a key clinical challenge, particularly during the hyperacute phase. This study aimed to assess…

Date: 2026-09-07

Gambling and screening for gambling problems in high school students before and after legal gambling age: associations with gender and gambling-related attitudes

Abstract: Adolescence is a period associated with increased risk of gambling problems. Although strict age limits should apply in modern digital gambling platforms, gambling in…

Date: 2026-09-07

Identification of key genes and metabolites in thyroid eye disease through integrated transcriptomic and metabolomic analysis

Abstract: Thyroid eye disease (TED) markedly compromises ocular function and quality of life, imposing significant healthcare and economic burdens. Present therapeutic strategies,…

Date: 2026-09-07

PQ-FundusChain: a postquantum blockchain framework for secure and privacy-preserving retinal fundus image sharing in teleophthalmology

Abstract: Teleophthalmology depends on secure exchange of retinal fundus images between primary care screening locations and referral centers. Current image-sharing systems remain…

Date: 2026-09-07