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Integrated single-cell and bulk transcriptomic analyses reveal cDC1-centered ubiquitination dysregulation and identify UBE2F as a critical regulator in sepsis

Abstract: Sepsis is a life-threatening syndrome with dysregulated immune responses and multiple organ dysfunction. However, precise diagnostic biomarkers and effective therapeutic…

Date: 2026-04-22

Perinatal depression impairs placental angiogenesis and fetal growth in mice: protective effects of betaine supplementation

Abstract: Perinatal depression (PND) is the most common psychiatric disorder experienced during pregnancy and postpartum and is characterized by persistent low mood, difficulty…

Date: 2026-04-22

Factors associated with depression in older adults during the COVID-19 pandemic: findings from The Irish Longitudinal Study on Ageing

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has adversely affected the physical and mental health of older adults worldwide. This study aimed to identify the…

Date: 2026-04-22

The temporal stability of core symptoms of social media addiction and their comorbidity with anxiety and depression in adolescents: a longitudinal network analysis

Abstract: Social media addiction (SMA) is often comorbid with anxiety and depression. This study examined the temporal stability of core SMA symptoms and the bridging symptoms…

Date: 2026-04-22

Posttraumatic stress in young children at risk for maltreatment: a causal data science analysis

Abstract: This article features the application of Causal Data Science (CDS) methods to determine the mechanism for Posttraumatic Stress (PTS) in young, maltreated children, in…

Date: 2026-04-22

Group CBT targeting hostile attribution bias in adolescents and young adults with ASD traits

Abstract: Adolescence is characterized by heightened self-consciousness and sensitivity to social evaluations. During this period, hostile attribution bias—interpreting ambiguous…

Date: 2026-04-22

AI-driven mental health decision support linked to clinician resilience and preparedness

Abstract: Mental health services are facing unprecedented demand, placing significant pressure on clinicians to conduct timely and effective patient assessments. Rising staff…

Date: 2026-04-22

Knowledge, attitude and practice of patients and their family members regarding age-related macular degeneration: a cross-sectional study

Abstract: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss among the older adults, and understanding the knowledge, attitudes, and practices…

Date: 2026-04-22

CSF-net: a color space fusion network with self-attention-driven feature learning for feline ocular diseases classification

Abstract: Feline ocular diseases can cause irreversible vision loss if they are not detected early. However, early diagnosis is often difficult. This is due to limited access to…

Date: 2026-04-22

Trends and inequities in fall- and musculoskeletal disorder–related mortality among U.S. adults aged 65 years and older, 1999–2023

Abstract: Musculoskeletal disorders (MSDs) and falls increasingly threaten U.S. older adults. Contemporary trend analyses are essential for targeted prevention. To assess national…

Date: 2026-04-22