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Ferroptosis-associated myeloid cell heterogeneity and inflammatory amplification following spinal cord injury

Abstract: Spinal cord injury (SCI) causes severe and persistent neurological dysfunction. Ferroptosis has been implicated in multiple neurological disorders, but its contribution…

Date: 2026-04-22

Construction and validation of a multimodal MRI-based quantitative feature prediction model for the prognosis of non-metastatic primary osteosarcoma

Abstract: Accurate prognosis assessment of non-metastatic primary osteosarcoma is essential for treatment decisions. This study aimed to develop and validate a pre-treatment…

Date: 2026-04-22

Identification of novel protein biomarkers for knee osteoarthritis by integrating human plasma proteome: evidence from Mendelian randomization and preliminary in vitro investigation

Abstract: This study sought to identify candidate plasma proteins with potential causal associations with knee osteoarthritis (KOA) through Mendelian randomization, and to provide…

Date: 2026-04-22

Percutaneous transforaminal endoscopic discectomy vs. unilateral biportal endoscopy for far lateral lumbar disc herniation: a retrospective comparative study

Abstract: To compare the early clinical efficacy, perioperative parameters, and safety profiles of percutaneous transforaminal endoscopic discectomy (PTED) and unilateral biportal…

Date: 2026-04-22

Integrated transcriptome and single-cell RNA sequencing identifies small GTPase-associated biomarkers in ulcerative colitis

Abstract: Ulcerative colitis (UC) is a chronic, multifactorial inflammatory bowel disease. The involvement of small GTPase-related genes (SGRGs) in UC remains poorly defined. This…

Date: 2026-04-22

Neutrophil count and platelet–lymphocyte ratio as simple predictors of ustekinumab response in patients with Crohn’s disease: a retrospective multicenter study

Abstract: Although ustekinumab (UST) has been recommended by guidelines as a parallel first-line biologic agent for Crohn’s disease (CD), its efficacy varies among individuals.…

Date: 2026-04-22

Incidence and risk factors of acute kidney injury among neurocritical patients in high-altitude regions: a retrospective cohort study

Abstract: Acute kidney injury (AKI) is a frequent complication in intensive care unit (ICU) patients with acute brain injury. High-altitude hypoxia may aggravate renal…

Date: 2026-04-22

Clinical predictive modeling for post-ERCP cholangitis in biliary stricture patients

Abstract: The objective of this study was to predict the occurrence of post-endoscopic retrograde cholangiopancreatography (ERCP) cholangitis (PEC) in patients with biliary…

Date: 2026-04-22

Familial hypobetalipoproteinemia in pediatric patients with fatty liver: an under-recognized cause

Abstract: Fatty liver is a leading cause of chronic liver disease in children, most often due to metabolic dysfunction-associated steatotic liver disease (MASLD). Fatty liver in…

Date: 2026-04-22

A single-center clinical study on the combination of Five-flavor sophora flavescens enteric-coated capsules and vedolizumab in induction therapy for ulcerative colitis

Abstract: The aim of this study was to evaluate the efficacy and safety of Vedolizumab (VDZ) combined with Five-flavor sophora flavescens enteric-coated capsules (FSEC) for…

Date: 2026-04-22