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IL-18 receptor axis in allergic conjunctivitis: a multi-omics study

Abstract: The pathophysiology of allergic conjunctivitis (AC) is not fully explained by the traditional Th2-centric model. This study aimed to identify AC-associated candidate…

Date: 2025-12-16

Utility of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in individuals with retinal vein occlusion

Abstract: The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) has recently been identified as a novel lipid marker for assessing…

Date: 2025-12-16

Clinical and economic evaluation of robotic vs. freehand screw fixation in femoral neck fractures: advancing precision alignment in orthopedics

Abstract: Femoral neck fractures are common and technically challenging injuries that often require internal fixation, with outcomes influenced by surgeon experience. This study…

Date: 2025-12-16

Metabolomic analysis of synovial fluid from healthy and pathological equine joints and tendon sheaths using high-resolution 1 H Nuclear Magnetic Resonance

Abstract: Joint and tendon sheath diseases are a major cause of lameness and reduced performance in horses. Synovial fluid composition changes in response to pathological…

Date: 2025-12-16

Individual components and cumulative burden of metabolic syndrome are associated with higher disease activity and adverse outcomes in Crohn’s disease

Abstract: The impact of metabolic syndrome (MetS) and its components on Crohn’s disease (CD) remains unclear. This study investigated how individual MetS factors and cumulative…

Date: 2025-12-16

Impact of stress hyperglycemia mediating tissue-level collaterals on futile recanalization in large vessel occlusion patients

Abstract: The stress hyperglycemia ratio (SHR) is associated with unfavorable functional outcomes in patients with large vessel occlusion. The potential effect of SHR on…

Date: 2025-12-16

Isolation of a nanobody specific to the PstS-1 protein and evaluation of its immunoreactivity with structural components of Mycobacterium tuberculosis granuloma

Abstract: Mycobacterium tuberculosis (Mtb) causes infectious granulomatous disease tuberculosis (TB), and existing in vitro TB-diagnosis is insensitive for extrapulmonary TB…

Date: 2025-12-16

Native C3 is activated without proteolytic cleavage by transformation to C3(H 2 O) on phospholipid-scrambled cell membranes

Abstract: Tick-over of C3 to fluid-phase C3(H 2 O) is considered the initiator of the alternative pathway by mediating random depositing of C3b on target surfaces. This slow…

Date: 2025-12-16

Temporal modulation of gene expression in a controlled Schistosoma mansoni human infection model

Abstract: Schistosomiasis is caused by parasitic blood flukes of the genus Schistosoma . Despite ongoing mass drug administration efforts, the disease remains a major public…

Date: 2025-12-16

CCL18: a potential immunosuppressive biomarker for prognosis in ABC diffuse large B-cell lymphoma

Abstract: Activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL) has worse outcomes than the germinal center B-cell (GCB) subtype, but underlying molecular mechanisms remain…

Date: 2025-12-15