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Evaluating the use of GLP-1 receptor agonists in Wolfram syndrome patients

Abstract: Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene and characterized by early-onset, insulin-dependent diabetes…

Date: 2026-07-30

Remission of polycystic ovary syndrome based on the recovery of ovarian morphology identified by three-dimensional ultrasonography: a retrospective study

Abstract: Polycystic ovary syndrome (PCOS) is a prevalent chronic disease, yet the concept of PCOS remission and its predictors remain poorly understood. This study investigated…

Date: 2026-07-30

Assessment of blood cobalt levels and safety of long-term hydroxocobalamin therapy in patients with cblC defect

Abstract: Hydroxocobalamin (OHCbl), the most effective form of vitamin B12 containing cobalt (Co) as its core component, is the mainstay therapy for cobalamin C (cblC) defect, yet…

Date: 2026-07-30

Sleep duration, sleep quality, and daytime napping in relation to incident cardiometabolic multimorbidity across three national aging cohorts: a prospective, interpretable machine learning study

Abstract: Sleep disturbances are modifiable factors linked to metabolic dysregulation, adiposity, blood pressure abnormalities, and cardiometabolic risk. Evidence remains limited…

Date: 2026-07-30

A novel solid beverage RLMCR prevents obesity-related metabolic disorders through the gut-adipose axis

Abstract: The global obesity epidemic and associated metabolic comorbidities have imposed an insurmountable strain on healthcare systems, underscoring the urgent need for simple,…

Date: 2026-07-30

Single-cell transcriptomic analysis of cutaneous squamous cell carcinoma identifies an NR1H3-associated angiogenic macrophage state

Abstract: Cutaneous squamous cell carcinoma (cSCC) is a common keratinocyte-derived malignancy whose progression is strongly influenced by the tumor microenvironment. Although…

Date: 2026-07-30

Persistent physical and mental health effects of COVID-19 hospitalization

Abstract: The long-term health effects of the COVID pandemic on children remain an area of active investigation. Viral infection, immune responses, and societal disruption have…

Date: 2026-07-30

Neonatal bronchopulmonary dysplasia severity and respiratory outcomes at 3 years of age: a prospective cohort study

Abstract: To examine whether bronchopulmonary dysplasia (BPD) severity is associated with pulmonary function abnormalities and asthma diagnosis risk at 3 years of age, and to…

Date: 2026-07-30

Co-designing Nova Sleepcare: exploring in-clinic, physician-delivered sleep education

Abstract: Youth with neurodevelopmental disorders (NDD) frequently experience behaviors of concern (BoC), such as aggression or self-injury, often exacerbated by sleep…

Date: 2026-07-30

Development and validation of a nomogram to predict the risk of deep venous thrombosis after hip replacement in elderly patients with femoral neck fracture

Abstract: The rising global aging population has led to more femoral neck fractures (FNF) in the elderly, posing a significant public health challenge. FNF patients undergoing hip…

Date: 2026-07-30