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Efficacy and safety analysis of PD-1 inhibitors combined with chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma

Abstract: This study aimed to assess the efficacy and safety of integrating programmed death-1 (PD-1) inhibitors with chemoradiotherapy (CRT) in the treatment of locally advanced…

Date: 2026-07-28

A novel lipid droplet-related prognostic signature reveals CIDEC as a key biomarker for pancreatic adenocarcinoma

Abstract: Reprogramming of lipid metabolism is acknowledged as a key characteristic of cancer. This research aimed to examine the potential of lipid droplet-associated genes…

Date: 2026-07-28

Prunetin ameliorates myocardial pyroptosis after myocardial infarction by inhibiting the TNF-?/p38 MAPK/ERK pathway

Abstract: The inflammatory response in cardiac tissue after myocardial infarction (MI) plays a critical role in myocardial injury. Prunetin (PRU), a natural flavonoid compound,…

Date: 2026-07-28

Synthetic T1 mapping using artificial intelligence and oxygenation-sensitive cardiovascular magnetic resonance for myocardial tissue characterization in hypertrophic cardiomyopathy and cardiac amyloidosis

Abstract: Cardiovascular magnetic resonance (CMR) techniques provide detailed myocardial tissue characterization. However, LGE requires the administration of contrast agents,…

Date: 2026-07-28

Peripheral blood endothelial microparticles (CD144+) as a surrogate marker for coronary microcirculatory dysfunction in patients with stable coronary artery disease

Abstract: In stable coronary artery disease (CAD), coronary microvascular dysfunction (CMD) is a prevalent cause of myocardial ischemia independent of epicardial stenoses.…

Date: 2026-07-28

The CALLY index as a novel predictor of left ventricular aneurysm in patients with ST-segment elevation myocardial infarction

Abstract: Left ventricular aneurysm (LVA) is a serious mechanical complication following ST-segment elevation myocardial infarction (STEMI). The C-reactive…

Date: 2026-07-28

Impact of CTO-related myocardial infarction and procedural success on long-term outcomes after CTO PCI

Abstract: The prognostic impact of CTO-related myocardial infarction (MI) and procedural success on long-term outcomes after chronic total occlusion (CTO) PCI remains uncertain.…

Date: 2026-07-28

Ultrasonic flow ratio versus Murray law-based quantitative flow ratio for predicting target vessel failure after IVUS-guided PCI

Abstract: Residual ischemia after percutaneous coronary intervention (PCI) is closely associated with adverse clinical outcomes. Murray law-based quantitative flow ratio (?QFR),…

Date: 2026-07-28

Dietary Inflammatory Index, cardiovascular health, and long-term outcomes in hypertension: external validation in a Chinese percutaneous coronary intervention cohort

Abstract: Hypertension frequently coexists with poor cardiovascular health (CVH), yet whether the inflammatory potential of habitual diet, captured by the Dietary Inflammatory…

Date: 2026-07-28

Single-cell and functional profiling identifies an IL6-centered immunometabolic communication circuit in multiple myeloma

Abstract: Multiple myeloma (MM) persists within a specialized bone marrow niche in which malignant plasma cells, immune dysfunction, inflammatory signaling, and metabolic stress…

Date: 2026-07-27