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Haploidentical, matched-related, and matched-unrelated hematopoietic cell transplant for acute leukemias in the early years of haploidentical transplant implementation in a developing country with a large unrelated donor registry

Abstract: Introduction: Over the last decades, the donor network for hematopoietic cell transplantation (HCT) has grown exponentially, including unrelated and haploidentical…

Date: 2025-04-15

Life’s Crucial 9 and psoriasis: a mediation analysis of systemic inflammation response index using NHANES cohort data

Abstract: Background: Psoriasis is a chronic, recurrent, inflammatory disease. The aim of this study was to investigate the association between the Life’s Crucial 9 (LC9) score…

Date: 2025-04-15

An inverted U-shaped association between high-sensitivity C-reactive protein and the albumin ratio and hepatic steatosis and liver fibrosis: a population-based study

Abstract: Background: The high-sensitivity C-reactive protein to albumin (CAR) ratio is a comprehensive measure of inflammation in vivo. Hepatic steatosis and fibrosis are…

Date: 2025-04-15

Development and validation of novel models based on clonality immunoglobulin gene rearrangement for evaluation of bone marrow involvement and prognostic prediction in patients with diffuse large B-cell Lymphoma: a multicenter retrospective study

Abstract: Introduction: Bone marrow involvement (BMI) is a poor prognostic factor in diffuse large B cell lymphoma (DLBCL), and accurate evaluation of BMI is crucial for…

Date: 2025-04-14

Evaluation of pulse therapy with intravenous methylprednisolone on leprosy neuritis in a Brazilian referral center

Abstract: Background: Leprosy neuritis (LN) is an immune hyperactivity majorly responsible for the deformities and sequelae present in leprosy disease. This observational study…

Date: 2025-04-14

Evoked craving in high-dose benzodiazepine users

Abstract: Introduction: Benzodiazepines (BDZs) are among the most abused substances worldwide, and high-dose BDZ abuse is considered a specific type of addiction. Cue reactivity…

Date: 2025-04-11

The patient journey and burden of disease in progressive pulmonary fibrosis in Japan: a cross-sectional survey

Abstract: Background: For patients with interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis (IPF) with a progressive pulmonary fibrosis (PPF) phenotype,…

Date: 2025-04-11

A novel teaching model using a massive online open course for soft skills development in the veterinary medicine curriculum

Abstract: Introduction: Teaching and learning methods in Higher Education are constantly adapting looking for a better achievement of one day competencies in each subject along…

Date: 2025-04-10

The association of neutrophil-to-lymphocyte ratio with post-chemotherapy pulmonary infection in lung cancer patients

Abstract: Background: Lung cancer patients are particularly vulnerable to pulmonary infections following chemotherapy, which can lead to suboptimal treatment outcomes and…

Date: 2025-04-09

Pathogenic KCNH2-G53S variant in the PAS domain influences the electrophysiological phenotype in long QT syndrome type 2

Abstract: Background: Long QT syndrome type 2 (LQT2) is an arrythmia caused by loss-of-function mutations in KCNH2, leading to impaired Kv11.1 channel function.

Date: 2025-04-09